different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-r-sulfoxide reductases不同的催化机制在哺乳动物硒代半胱氨酸,cysteine-containing methionine-r-sulfoxide还原酶.pdfVIP

Open access, freely available online PLoS BIOLOGY Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases * Hwa-Young Kim, Vadim N. Gladyshev Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many se