dicer is associated with ribosomal dna chromatin in mammalian cells帽子与核糖体dna在哺乳动物细胞染色质.pdfVIP

Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells Lasse Sinkkonen¤b. , Tabea Hugenschmidt., Witold Filipowicz*, Petr Svoboda¤a* Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland Abstract Background: RNA silencing is a common term for pathways utilizing small RNAs as sequence-specific guides to repress gene expression. Components of the RNA silencing machinery are involved in different aspects of chromatin function in numerous organisms. However, association of RNA silencing with chromatin in mammalian cells re