disc1 regulates primary cilia that display specific dopamine receptorsdisc1调节初级纤毛显示特定的多巴胺受体.pdfVIP

DISC1 Regulates Primary Cilia That Display Specific Dopamine Receptors Aaron Marley, Mark von Zastrow* Departments of Psychiatry and Cellular Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America Abstract Background: Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identified a role of DISC1 i