原创力文档discovery of genes activated by the mitochondrial unfolded protein response (mtupr) and cognate promoter elements发现线粒体的基因激活的蛋白质反应(mtupr)和同源启动子元素.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
discovery of genes activated by the mitochondrial unfolded protein response (mtupr) and cognate promoter elements发现线粒体的基因激活的蛋白质反应(mtupr)和同源启动子元素
Discovery of Genes Activated by the Mitochondrial
Unfolded Protein Response (mtUPR) and Cognate
Promoter Elements
Jonathan E. Aldridge, Tomohisa Horibe, Nicholas J. Hoogenraad*
Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia
In an accompanying paper, we show that the mitochondrial Unfolded Protein Response or mtUPR is initiated by the activation
of transcription of chop through an AP-1 element in the chop promoter. Further, we show that the c/ebpb gene is similarly
activated and CHOP and C/EBPb subsequently hetero-dimerise to activate transcription of mtUPR responsive genes. Here, we
report the discovery of six additional mtUPR responsive genes. We found that these genes encoding mitochondrial proteases
YME1L1 and MPPb, import component Tim17A and enzymes NDUFB2, endonuclease G and thioredoxin 2, all contain a CHOP
element in their promoters. In contrast, genes encoding mitochondrial proteins Afg3L2, Paraplegin, Lon and SAM 50, which do
not have a CHOP element, were not up-regulated. Conversely, genes with CHOP elements encoding cytosolic proteins were not
induced by the accumulation of unfolded proteins in mitochondria. These results indicate that mtUPR responsive genes appear
to share a requirement for a CHOP element, but that this is not sufficient for the regulation of the mtUPR. A more detailed
analysis of promoters of mtUPR responsive genes revealed at least two additional highly conserved, putative regulatory sites
either side of the CHOP element, one a motif of 12 bp which lies 14 bp upstream of the CHOP site and another 9 bp element,
2 bp downstream of the CHOP site. Both of these additional elements are conserved in the promoters of 9 of the ten mtUPR
responsive genes we have identified so far, the exception being the Cpn60/10 bidirectional promoter. Mutation of each of
these elements substantially reduced the mtUPR responsiveness of the promoters suggesting that these elements coordinately
r
您可能关注的文档
- development of the fc-iii tagged protein expression system for protein purification and detection发展fc-iii标记蛋白表达系统的蛋白质纯化和检测.pdf
- development of the jackson heart study coordinating center杰克逊心脏研究协调中心的发展.pdf
- development of transgenic mice containing an introduced stop codon on the human methylmalonyl-coa mutase locus发展转基因老鼠包含一个终止密码子介绍人类methylmalonyl-coa变位酶位点.pdf
- development, methodology and potential of the new universal visual scoring system (univiss) for caries detection and diagnosis开发方法和潜在的新通用的视觉评分系统(univiss)龋齿检测和诊断.pdf
- development of transgenic cloned pig models of skin inflammation by dna transposon-directed ectopic expression of human β1 and α2 integrin发展转基因克隆了猪的皮肤炎症模型dna transposon-directed异位表达人类β1和α2整合素.pdf
- developmental and pathological changes in the human cardiac muscle mitochondrial dna organization, replication and copy number发育和病理变化在人类心肌线粒体dna组织、复制和拷贝数.pdf
- developmental changes in the metabolic network of snapdragon flowers发展变化的代谢网络的金鱼草的花.pdf
- developmental changes in emotion recognition from full-light and point-light displays of body movement发展变化的情感识别完整和光电显示身体的运动.pdf
- developmental defects in mutants of the psbp domain protein 5 in arabidopsis thalianapsbp域的发育缺陷突变体拟南芥蛋白5.pdf
- developmental exposure to bisphenol a modulates innate but not adaptive immune responses to influenza a virus infection发展暴露在双酚a调节天生的但不是甲型流感病毒感染的适应性免疫反应.pdf
- disabled-1 alternative splicing in human fetal retina and neural tumorsdisabled-1可变剪接在人类胎儿视网膜和神经肿瘤.pdf
- discovery of inhibitors of leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library发现的抑制剂利什曼虫β-1,2-mannosyltransferases使用click-chemistry-derived鸟苷酸库.pdf
- discovery and potential of snp markers in characterization of tunisian olive germplasm发现和潜在的snp标记在突尼斯油橄榄种质特性.pdf
- discovery of defense- and neuropeptides in social ants by genome-mining发现的防御和神经肽在社会蚂蚁基因组挖掘.pdf
- discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation发现分子内信号转导网络基于一种新的蛋白质能量耗散的动力学模型.pdf
- discovery of new eunicellins from an indonesian octocoral cladiella sp.新发现的eunicellins从印尼octocoral cladiella sp。.pdf
- discovery of molecular mechanisms of traditional chinese medicinal formula si-wu-tang using gene expression microarray and connectivity map发现中国传统药用公式的分子机制si-wu-tang使用基因表达微阵列和连接地图.pdf
- discovery of an auto-regulation mechanism for the maltose abc transporter malfgk2发现一个abc运输车malfgk2麦芽糖auto-regulation机制.pdf
- discovery of nuclear-encoded genes for the neurotoxin saxitoxin in dinoflagellates发现nuclear-encoded基因的神经毒素在鞭毛藻类贝类毒素.pdf
- discovery of potential pirnas from next generation sequences of the sexually mature porcine testes发现潜在pirnas下一代序列性的成熟猪睾丸.pdf
文档评论（0）