disruption of the toxoplasma gondii parasitophorous vacuole by ifnγ-inducible immunity-related gtpases (irg proteins) triggers necrotic cell death刚地弓形虫parasitophorous泡的破坏ifnγ-inducible immunity-related gtpase(irg蛋白质)触发坏死细胞死亡.pdfVIP

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNc-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death Yang O. Zhao, Aliaksandr Khaminets, Julia P. Hunn, Jonathan C. Howard* Institute for Genetics, University of Cologne, Cologne, Germany Abstract Toxoplasma gondii is a natural intracellular protozoal pathogen of mice and other small mammals. After infection, the parasite replicates freely in many cell types (tachyzoite stage) before undergoing a phase transition and encysting in brain and muscle (brad