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- 2017-09-12 发布于上海
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diverse roles of ephephrin signaling in the mouse lens不同的角色在鼠标透镜ephephrin信号
Diverse Roles of Eph/ephrin Signaling in the Mouse Lens
Catherine Cheng, Xiaohua Gong*
School of Optometry and Vision Science Program, University of California, Berkeley, California, United States of America
Abstract
Recent genetic studies show that the Eph/ephrin bidirectional signaling pathway is associated with both congenital and
age-related cataracts in mice and humans. We have investigated the molecular mechanisms of cataractogenesis and the
roles of ephrin-A5 and EphA2 in the lens. Ephrin-A5 knockout (-/-) mice often display anterior polar cataracts while EphA
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