dna display selection of peptide ligands for a full-length human g protein-coupled receptor on cho-k1 cellsdna显示选择的肽配体完整的人类g protein-coupled cho-k1细胞上受体.pdfVIP

DNA Display Selection of Peptide Ligands for a Full- Length Human G Protein-Coupled Receptor on CHO-K1 Cells Nobuhide Doi*, Natsuko Yamakawa, Hideaki Matsumoto, Yasutsugu Yamamoto, Tetsuya Nagano, Nobutaka Matsumura¤, Kenichi Horisawa, Hiroshi Yanagawa Department of Biosciences and Informatics, Keio University, Yokohama, Japan Abstract The G protein-coupled receptors (GPCRs), which form the largest group of transmembrane proteins involved in signal transduction, are major targets of currently available drugs. Thus, the search for cognate and surrogate pept