dna damage triggers genetic exchange in helicobacter pyloridna损伤引起幽门螺杆菌基因交换.pdfVIP

DNA Damage Triggers Genetic Exchange in Helicobacter pylori Marion S. Dorer, Jutta Fero, Nina R. Salama* Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America Abstract Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation