dntp supply gene expression patterns after p53 loss核苷酸供应后p53基因表达模式的损失.pdfVIP

Cancers 2012, 4, 1212-1224; doi:10.3390/cancers4041212 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article dNTP Supply Gene Expression Patterns after P53 Loss Tomas Radivoyevitch 1,*, Yogen Saunthararajah 2, John Pink 1, Gina Ferris 3, Ian Lent 1, 1 1 3 Mark Jackson , Damian Junk and Charles A. Kunos 1 Departments of Epidemiology and Biostatistics, General Medical Sciences (Oncology), and Pathology, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA; E-Mails: jrp16@ (J.P.); ijl4@ (I.L.); mwj7@ (M.J.); djj40@ (D.J.) 2 Department of Translational Hematology Oncology Research, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Ave. R40, Cleveland, OH 44195, USA; E-Mail: saunthy@ 3 Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA; E-Mails: gjf3@ (G.F.); charles.kunos@UH (C.A.K.) * Author to whom correspondence should be addressed; E-Mail: txr24@; Tel.: +1-216-368-1965; Fax: +1-216-368-1969. Received: 27 October 2012; in revised form: 27 October 2012 / Accepted: 15 November 2012 / Published: 20 November 2012 Abstract: Loss of the transcription factor p53 implies mRNA losses of target genes such as the p53R2 subunit of human ribonucleotide reductase (RNR). We hypothesized that other genes in the dNTP supply system would compensate for such p53R2 losses and looked for this in our own data and in data of the Gene Expression Omnibus (GEO). We