原创力文档do natural proteins differ from random sequences polypeptides natural vs. random proteins classification using an evolutionary neural network做自然蛋白质多肽自然不同于随机序列和随机蛋白质分类使用一个进化神经网络.pdfVIP
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do natural proteins differ from random sequences polypeptides natural vs. random proteins classification using an evolutionary neural network做自然蛋白质多肽自然不同于随机序列和随机蛋白质分类使用一个进化神经网络
Do Natural Proteins Differ from Random Sequences
Polypeptides? Natural vs. Random Proteins Classification
Using an Evolutionary Neural Network
1 2 1,2 3,4 1
Davide De Lucrezia , Debora Slanzi , Irene Poli , Fabio Polticelli , Giovanni Minervini *
1 European Centre for Living Technology, University Ca’ Foscari Venice. Venice, Italy, 2 Dept. of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari
Venice, Venice, Italy, 3 Dept. of Biology, University of Roma Tre. Rome, Italy, 4 National Institute for Nuclear Physics, Roma Tre Section. Rome, Italy
Abstract
Are extant proteins the exquisite result of natural selection or are they random sequences slightly edited by evolution? This
question has puzzled biochemists for long time and several groups have addressed this issue comparing natural protein
sequences to completely random ones coming to contradicting conclusions. Previous works in literature focused on the
analysis of primary structure in an attempt to identify possible signature of evolutionary editing. Conversely, in this work we
compare a set of 762 natural proteins with an average length of 70 amino acids and an equal number of completely random
ones of comparable length on the basis of their structural features. We use an ad hoc Evolutionary Neural Network
Algorithm (ENNA) in order to assess whether and to what extent natural proteins are edited from random polypeptides
employing 11 different structure-related variables (i.e. net charge, volume, surface area, coil, alpha helix, beta sheet,
percentage of coil, percentage of alpha helix, percentage of beta sheet, percentage of secondary structure and surface
hydrophobicity).
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