downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens整合素的downregulationβ4减少气道上皮细胞呈现抗原的能力.pdfVIP

Downregulation of Integrin b4 Decreases the Ability of Airway Epithelial Cells to Present Antigens Chi Liu, Xiaoqun Qin*, Huijun Liu, Yang Xiang Physiology Department, Xiangya Medical School, Central South University, Changsha, Hunan, People’s Republic of China Abstract Airway epithelial cells have been demonstrated to be accessory antigen presentation cells (APC) capable of activating T cells and may play an important role in the development of allergic airway inflammation of asthma. In asthmatic airways, loss of expression of the adhesion molecule integrin b4 (ITG