dynamic, morphotype-specific candida albicans β-glucan exposure during infection and drug treatment动态、morphotype-specific白色念珠菌β-glucan暴露在感染和药物治疗.pdfVIP

Dynamic, Morphotype-Specific Candida albicans b- Glucan Exposure during Infection and Drug Treatment ¤ Robert T. Wheeler *, Diana Kombe, Sudeep D. Agarwala, Gerald R. Fink Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America Abstract Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall b- glucan from immune recognition, mutes protective host responses mediated by the Dectin-1 b-glucan receptor on innate immune cells. Although