dysferlin forms a dimer mediated by the c2 domains and the transmembrane domain in vitro and in living cellsdysferlin形成二聚体由c2域和跨膜域体外和活细胞.pdfVIP

Dysferlin Forms a Dimer Mediated by the C2 Domains and the Transmembrane Domain In Vitro and in Living Cells Li Xu, Sandeep Pallikkuth, Zhanjia Hou, Gregory A. Mignery, Seth L. Robia, Renzhi Han* Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America Abstract Dysferlin was previously identified as a key player in muscle membrane repair and its deficiency leads to the development of muscular dystrophy and cardiomyopathy. However, little is known about the oligomerization of thi