e2f1 regulates cellular growth by mtorc1 signalinge2f1 mtorc1信号调节细胞生长.pdfVIP

E2F1 Regulates Cellular Growth by mTORC1 Signaling Sebastian Real, Nathalie Meo-Evoli, Lilia Espada, Albert Tauler* ´ ` Departament de Bioquımica i Biologia Molecular, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain Abstract During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1’s a