ebv latency types adopt alternative chromatin conformationsebv延迟类型采用替代染色质构象.pdfVIP

EBV Latency Types Adopt Alternative Chromatin Conformations Italo Tempera, Michael Klichinsky, Paul M. Lieberman* The Wistar Institute, Philadelphia, Pennsylvania, United States of America Abstract Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization. Here we explore the three-dimensional conformations of the EBV genome in different latency types. We employed Chromosome Conformation Ca