effects of hypoxia exposure on hepatic cytochrome p450 1a (cyp1a) expression in atlantic croaker molecular mechanisms of cyp1a down-regulation缺氧暴露对肝细胞色素p450 1(cyp1a)表达在大西洋嘎声的分子机制的cyp1a下调.pdfVIP

Effects of Hypoxia Exposure on Hepatic Cytochrome P450 1A (CYP1A) Expression in Atlantic Croaker: Molecular Mechanisms of CYP1A Down-Regulation Md. Saydur Rahman*, Peter Thomas Marine Science Institute, University of Texas at Austin, Port Aransas, Texas, United States of America Abstract Hypoxia-inducible factor-a (HIF-a) and cytochrome P450 1A (CYP1A) are biomarkers of environmental exposure to hypoxia and organic xenobiotic chemicals that act through the aryl hydrocarbon receptor, respectively. Many aquatic environments heavily contaminated with organic chemicals