endothelial neuropilin disruption in mice causes digeorge syndrome-like malformations via mechanisms distinct to those caused by loss of tbx1内皮neuropilin老鼠破坏导致先天性胸腺发育不全症状畸形通过机制造成的损失tbx1截然不同.pdfVIP

Endothelial Neuropilin Disruption in Mice Causes DiGeorge Syndrome-Like Malformations via Mechanisms Distinct to Those Caused by Loss of Tbx1 Jingjing Zhou, Mohammad Pashmforoush, Henry M. Sucov* Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America Abstract The spectrum of human congenital malformations known as DiGeorge syndrome (DGS) is replicated in mice by mutation of Tbx1. Vegfa has been proposed as a modifier of DGS, based in p