原创力文档essential role of cdc42 in ras-induced transformation revealed by gene targeting重要作用的cdc42诱发性转换通过基因打靶.pdfVIP
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essential role of cdc42 in ras-induced transformation revealed by gene targeting重要作用的cdc42诱发性转换通过基因打靶
Essential Role of Cdc42 in Ras-Induced Transformation
Revealed by Gene Targeting
Kristy R. Stengel, Yi Zheng*
Division of Experimental Hematology and Cancer Biology, Children’s Research Foundation; Department of Cancer and Cell Biology, College of Medicine, University of
Cincinnati, Ohio, United States of America
Abstract
The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of
activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant
Ras
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