《兽医内科学》重点知识梳理第三章（Third chapters of key knowledge of Veterinary Internal Medicine）.doc

《兽医内科学》重点知识梳理第三章（Third chapters of key knowledge of Veterinary Internal Medicine） The third chapter liver disease Clinical syndrome of liver disease Hemorrhagic diathesis Neurological symptoms Edema and ascites Anorexia, vomiting, diarrhea, constipation syndrome Hepatomegaly, liver pain jaundice Photosensitivity Haematological changes Clinical syndrome of liver disease Hemorrhagic diathesis The absorption of VK was influenced by prothrombin and inhibited by thrombin. Choline is involved in the digestion and absorption of fat soluble vitamins in bile. While VK is in the process of coagulation factors II, V, VII, IX, the precursor to the coagulation factor. In the absence of VK, these clotting factors eventually fail to synthesize Prothrombin synthesis is insufficient, blood coagulation time is prolonged In the process of coagulation of fibrinogen and coagulation factor VII, both in the liver synthesis. Clinical syndromes of liver disease: neurological symptoms Liver detoxification function When severe hepatic insufficiency, endogenous or exogenous toxic substances can not be metabolized in the liver detoxification, accumulate in the blood, leading to central nervous system disorders, is one of the most important factors of hepatic encephalopathy. hepatic encephalopathy Hepatic coma, a syndrome characterized by central nervous system dysfunction, is caused by the inability of the liver to remove toxic metabolites from the blood. It is a series of neurological symptoms characterized by coma. The sick animals initially appeared manic, convulsions, disturbed consciousness, and then fell asleep. Pathogenesis of hepatic encephalopathy It is not fully understood that factors such as ammonia intoxication, hypoglycemia, disorders of water and electrolyte metabolism and acid-base disturbance are considered to affect the central nervous system. Elevated blood ammonia Source: endogenous or exogenous Detoxification pathway: ammonia is detoxified in the liver by the synthesis of u