(欧兰宁)奥氮平说明书（(Ou Lanning) olanzapine manual）.docVIP

(欧兰宁)奥氮平说明书（(Ou Lanning) olanzapine manual） [Olanzapine Tablets indications] Olanzapine is suitable for the treatment of schizophrenia and other acute and persistent psychosis with severe positive symptoms and / or negative symptoms. It can also relieve secondary emotional symptoms of schizophrenia and related diseases. [function and indications] Olanzapine is suitable for the treatment of schizophrenia and other acute and persistent psychosis with severe positive symptoms and / or negative symptoms. It can also relieve secondary emotional symptoms of schizophrenia and related diseases. [taboo items] This product is contraindicated in patients who are known to be allergic to olanzapine. This product is carefully used in patients with the following conditions: 1 have epilepsy history or have epilepsy related disease; 2 any cause of leukocyte and / or neutrophil depression; 3 drug induced myelosuppression / history of toxic reactions; 4 bone marrow suppression caused by radiotherapy or chemotherapy; 5 eosinophilic diseases or myeloproliferative diseases; 6 BPH, paralytic ileus and narrow angle glaucoma. [drug interaction] P450 cytochrome variants, especially CYP1A2 inhibitors and inducers, can delay and shorten the clearance rate of olanzapine, respectively. Smoking and C Masi Bing increased the clearance rate of olanzapine. The following drugs and a single dose of olanzapine combined with medication, no metabolic inhibition: imipramine and its metabolite desipramine, warfarin, theophylline or diazepam. There was no interaction between olanzapine and lithium salts and the combined use of piperacillin. A single dose of aluminum or magnesium antacid, cimetidine, had no effect on olanzapine bioavailability, whereas the use of activated charcoal reduced olanzapine bioavailability by 50 to 60%. [drug overdose] In clinical trials, 67 patients had intentional or unintentional overdose, maximum dose of 300mg (normal daily dose of 5 ~ 20mg), symptoms only drowsiness and slurre