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【心血管系统部分笔记】([cardiovascular system notes])
【心血管系统部分笔记】([cardiovascular system notes])
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[cardiovascular system notes]
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[cardiovascular system notes]
King7988 1, Lou Zhu
AS good site: artery bifurcation, arterial branch opening, convex curved blood vessels
(1) basic lesion
1. fat streak: an early lesion in AS
This is a reversible change that can occur in childhood at the earliest.
2. fiber plaques
Further developed from lipid streaks
The naked eye: raised on the inner surface of the intima, porcelain white, like white candle oil, irregular plaques, glassy collagen fibers
Under the microscope: the plaque surface is a layer of dense fibrous cap, hyperplasia of smooth muscle cells, a small amount of elastic fibers, proteoglycans, fibrous cap with different amounts of foam cells, extracellular lipid and inflammatory cells, smooth muscle cells.
The 3. atheromatous plaque is also called atheroma
Lipid release, formation, enrichment
Cytotoxicity of OX-LDL is yellow in lipid pool of foam cholesterol ester
Endothelial cells, SMC produce oxygen free radical cells, sticky porridge
Releasing lysosomal enzymes to make plaque like substances
The cells were further necrotic and disintegrated
Gradually develop fibrous plaques into atheromatous plaques. Atheromatous plaques are typical lesions of AS.
4. secondary lesions
? intra plaque hemorrhage
? plaque rupture; formation of atheromatous ulcer
? thrombosis
? calcification or even ossification
? aneurysm formation
? ischemic changes of tissues and organs
(two) the main artery lesions (important organ lesions)
1. aortic atherosclerosis:
? most of the lesions occurred at the posterior wall of the aorta and the openings of their branches.
#8226 was the most serious abdominal aortic lesion, followed by the thoracic aorta and the lowes
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