CA 153及CEA联合检测对乳腺癌术后监测意义.doc

CA 153及CEA联合检测对乳腺癌术后监测意义 　【摘要】 　　目的观察CA 153和CEA联合检测在乳腺癌术后监测中的价值。方法120例乳腺癌术后患者，空腹取静脉血，分别采用免疫放射分析法(IRMA)和放射免疫分析法(RIA)测定CA 153和CEA。结果①乳腺癌术后无复发转移100例，其中CA 153增高4例、CEA增高3例，阳性率分别为4.0%、3.0%。复发转移20例，其中CA 153增高15例、CEA增高11例，敏感度分别为75.0%、55.0%。CA 153和CEA两者均异常，在无复发转移组为0，复发转移组6例，其敏感度为30.0%，联检两者之一阳性14例，其敏感度为70.0%，联检与单独检测CA 153比较无显著性差异(P＞0.05)。②复发或转移乳腺癌患者CA 153和CEA水平显著高于无复发或无转移乳腺癌患者(P＜0.01)。结论CA 153和CEA的检测可作为乳腺癌术后随访的重要指标，对预测复发转移具有重要意义。 【关键词】 细胞膜糖蛋白CA 153　 癌胚抗原　 乳腺癌 　　The Monitoring Significance of Serum Concentrations CA 153 and CEA in the Postoperative Patients with Breast Cancer 　　【Abstract】ObjectiveTo investigate the significance of combined detection of CA 153 and CEA in the postoperative patients with breast cancer. MethodsThe concentrations of CA 153 and CEA were respectively detected by IRMA and RIA in blood. Results① The levels of CA 153 in 4 cases and CEA in 3 cases were increased in the 100 postoperative breast cancer patients without recurrence and metastasis,and the positive rate is 4.0% and 3.0% respectively. In the 20 cases with recurrence and metastasis, 15 patients were measured with higher CA 153 and 11 patients with higher CEA,which the sensitivity is 75.0% and 55.0% respectively.14 positive patients were detected by either of the methods,which the sensitivity is 70.0%. Combined detection had no significant difference compared with CA 153 alone. No case in patients without recurrence and metastasis and 6 cases in patients with metastasis and recurrence were detected for both CA 153 and CEA concurrent abnormality, its sensitivity is 30.0%. ②The level of CA 153 or CEA is significantly higher in the breast cancer patients with metastasis and recurrence than that in those metastasis and recurrence. ConclusionThe detection of CA 153 and/or CEA can be an important index for the followup to the postoperative breast cancer, and is important for predicting the recurrence and metastasis of breast cancer. 　　【Key words】CA 153； Carcinoembryonic antigen； B