β3肾上腺素能受体心血管调节及信号转导.docVIP

β3肾上腺素能受体心血管调节及信号转导 　【摘要】 目的 β肾上腺素能受体( β-Adrenergic Receptor, β-AR)在体内多种脏器组织中均有分布，与经典 1、 2-AR在结构和功能上均有着显著的差异， β-AR与G蛋白耦联，经β3-AR/NO、cAMP/PKA信号转导通路参与心血管功能活动的调节，兴奋后能够直接降低心肌收缩力，舒张血管平滑肌，参与组织器官间的血流分配调节。 【关键词】 β3-肾上腺素能受体;心血管调节;信号转导 【Abstract】 β3adrenergic receptor (AR) exists in various organs and tissues and is different from β1 and β2-AR in construction and function. β3-adrenergic receptor belongs to the G protein-coupled receptors family (GPCRs) and can regulate the function of cardiovascular by β3-AR/NO and cAMP/PKA signal transduction pathways. Stimulation of the β3-AR by agonists can decrease