出院维持治疗抑郁症患者复发相关因素分析.docVIP

出院维持治疗抑郁症患者复发相关因素分析 　【摘要】 目的 探讨抗抑郁剂维持治疗过程中抑郁症患者复发的相关因素。 方法 将157例坚持服用抗抑郁剂治疗的抑郁症患者中45例复发者设为复发组，未复发者设为对照组；采用自拟问卷统计患者的一般情况，采用生活事件量表、社会支持评定量表、防御方式问卷评定患者的生活事件、社会支持状况及防御方式，并进行对比分析。 结果 抑郁症患者维持服用抗抑郁剂治疗复发率为28.66%；复发组女性构成比高，年龄偏高，家族史明显，伴精神病性症状、躯体化症状及焦虑症状更明显（P均＜0.01）。生活事件量表、社会支持评定量表、防御方式问卷评分复发组正性刺激量、负性刺激量和总刺激量、客观支持、不成熟和中间型防御方式因子分均显著高于对照组（P＜0.05或0.01）；社会支持、主观支持及支持利用度因子分均显著低于对照组（P＜0.05或0.01）。结论 抑郁症患者维持服用抗抑郁剂治疗过程中，症状复发者与患者的一般情况、生活事件、社会支持度、防御方式有关。 【关键词】 抑郁症；抗抑郁剂；维持治疗；复发；生活事件；社会支持；防御方式 【Abstract】 Objective To explore the relapse correlation factors during antidepressants maintenance therapy in depression. Methods 45 patients who relased were assigned to relase group and 112 ones who didn’t to control group from oneyear followedup 157 ones having being taken antidepressants; general conditions were added up,and life events, status of social support and defense styles assessed and contrastively analysed with the Life Event Scale(LES), Social Support Rating Scale（SSRS）and Defense Style Questionnaire（DSQ）. Results The relapse rate of depression patients on antidepressants maintenance therapy was 28.66%; features of the relase group were more female, higher age, more evident family history as well as more obvious psychotic, somatization and anxiety symptoms(all Plt;0.01). Scores of positive,negative and total quantity of timulus, objective support, immaturiy and medial type of defense style were significantly higher(Plt;0.05 or 0.01) and those of social and subjective support as well as support availability lower(Plt;0.05 or 0.01) in the relase than in the control group. Conclusion Symptoms’ relapses of depression patients on antidepressants maintenance therapy are related to patients’ general conditions, life events, social support and defense style. 【Keywords】 Depression; antidepressants; maintenance therapy; relapse; life event; social support； defense style 抑郁症是一种慢性发作性疾病，具有较高的患病率与死亡率，已成为严重危害人类健康的疾病之一。目前药物治疗仍是治疗抑郁症的主要方法，尽管对抑郁症患者予以长期抗抑郁剂维持治疗，但仍有部分患者在长期服用抗抑郁剂维持治疗过程中出现反复发作。本文对抗抑郁剂维持