the proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas颈板分子签名丰富少突神经胶质瘤和预测提高弥漫性神经胶质瘤中生存.pdfVIP

The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas 1 1 3,4 4 1 1 Lee A. D. Cooper , David A. Gutman , Qi Long , Brent A. Johnson , Sharath R. Cholleti , Tahsin Kurc , Joel H. Saltz1,2,3, Daniel J. Brat1,2,3, Carlos S. Moreno1,2,3* 1 Center for Comprehensive Informatics, Emory University, Atlanta, Georgia, United States of America, 2 Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, 3 Emory Winship Cancer Institute, Atlanta, Georgia, United States of America, 4 Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America Abstract The Cancer Genome Atlas Project (TCGA) has produced an extensive collection of ‘-omic’ data on glioblastoma (GBM), resulting in several key insights on expression signatures. Despite the richness of TCGA GBM data, the absence of lower grade gliomas in this data set prevents analysis genes related to progression and the uncovering of predictive signatures. A complementary dataset exists in the form of the NCI Repository for Molecular Brain Neoplasia Data (Rembrandt), which contains molecular and clinical data for diffuse gliomas across the full spectrum of histologic class and grade. Here we present an investigation of the significance of the TCGA consortium’s expression classification when applied to Rembrandt gliomas. We demonstrate that the proneural signature predicts improved clinical outcome among 176 Rembrandt gliomas that includes all histologies and grades, including GBMs (log rank test p = 1.16e-6), but also among 75 grade II and grade III samples (p = 2.65