原创力文档single nucleotide polymorphisms in il1b and the risk of acute coronary syndrome a danish case-cohort study单核苷酸多态性在il1b和急性冠脉综合征的风险丹麦case-cohort研究.pdfVIP
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single nucleotide polymorphisms in il1b and the risk of acute coronary syndrome a danish case-cohort study单核苷酸多态性在il1b和急性冠脉综合征的风险丹麦case-cohort研究
Single Nucleotide Polymorphisms in IL1B and the Risk of
Acute Coronary Syndrome: A Danish Case-Cohort Study
1 1 2 3
Jakob Gerhard Stegger *, Erik Berg Schmidt , Anne Tjønneland , Tine Iskov Kopp ,
Thorkild I. A. Sørensen4, Ulla Vogel5., Kim Overvad 1,6.
1 Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, 2 Danish Cancer Society Research
Center, Copenhagen, Denmark, 3 National Food Institute, Technical University of Denmark, Soborg, Denmark, 4 Institute of Preventive Medicine, University of
Copenhagen, Copenhagen, Denmark, 5 National Research Centre for the Working Environment, Copenhagen, Denmark, 6 Department of Epidemiology, School of Public
Health, Aarhus University, Aarhus, Denmark
Abstract
Background: Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of
atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide
polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The
aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region
of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk
factors for ACS on an additive scale.
Methodology/Principal Findings: The present study was based on the Danish prospective study Diet, Cancer and Health
comprising more than 57 000 participants aged 50–64 at baseline. During a median follow-up of 7.2 years we identified 989
cases of incident ACS (755 men and 234 women). All cases were validated by review of medical records, an
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