[5-(1,3-diphenyl-1h-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol-1-yl](pyridin-4-yl)methanone英文论文.pdfVIP

Molbank 2011, M714; doi:10.3390/M714 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note [5-(1,3-Diphenyl-1H-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol- 1-yl](pyridin-4-yl)methanone Darpan Kaushik *, Upasana Nagpal, Tarawanti Verma and Kapish Madan Department of Pharmaceutical Chemistry, RITS, 4th Mile Stone, Hisar Road, Sirsa-125055, India * Author to whom correspondence should be addressed; E-Mail: darpkaush@. Received: 13 December 2010 / Accepted: 4 January 2011 / Published: 11 January 2011 Abstract: A novel pyrazoline derivative 2 was synthesized by reaction of an α,β-unsaturated ketone 1 with isonicotinic acid hydrazide (INH) in glacial acetic acid. The structure of the title compound 2 was established on basis of IR, 1H-NMR, 13C-NMR and mass spectral data. Keywords: chalcone; pyrazoline; isonicotinic acid hydrazide 1. Introduction Pyrazoline derivatives are electron-rich nitrogen heterocycles which play an important role due to their diverse biological activities [1]. They have been found to possess antimicrobial, antidiabetic, antidepressant, anticancer, hypotensive, antiamoebic, anti-inflammatory and antitubercular activity [2-10]. As a part of our research programme on pyrazoline derivatives [11], we report herein the synthesis of [5-(1,3-diphenyl-1H-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol-1-yl](pyridin-4-yl)methanone (2). 2. Results Discussion The title compound 2 was prepared by reaction of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-1-phenylprop- 2-en-1-one (1) and isonicotinic acid hydraz