3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3h-chromeno [2,3-d ]pyrimidine an effecient key precursor for novel synthesis of some interesting triazines and triazepines as potential anti-tumor agents英文论文.pdfVIP
- 1、本文档共16页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3h-chromeno [2,3-d ]pyrimidine an effecient key precursor for novel synthesis of some interesting triazines and triazepines as potential anti-tumor agents英文论文
Molecules 2012, 17, 11538-11553; doi:10.3390/molecules171011538
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
3-Amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-
chromeno [2,3-d ]pyrimidine: An Effecient Key Precursor for
Novel Synthesis of Some Interesting Triazines and Triazepines
as Potential Anti-Tumor Agents
Mohamed G. Badrey 1 and Sobhi M. Gomha 2,*
1 Chemistry Department, Faculty of Science, Fayoum University, El-Fayoum, 63514, Egypt;
E-Mail: mohammedgomaa2006@
2 Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt
* Author to whom correspondence should be addressed; E-Mail: s.m.gomha@;
Tel.: +20-237-400-304; Fax: +20-225-685-799.
Received: 6 August 2012; in revised form: 27 August 2012 / Accepted: 20 September 2012 /
Published: 27 September 2012
Abstract: A number of interesting heterocycles were prepared through interaction of the
intermediate 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno-
[2,3-d]pyrimidine (1) and reagents such as hydrazonyl halides 2 to furnish triazine
derivatives 4a–l. Reaction of 1 with phenacyl bromide afforded compound 5. Moreover,
the title compound 1 was subjected to condensation with active methylene compounds
(ethyl acetoacetate and ethyl benzoylacetate) to give triazipinones 8a,b. The condensation
with aromatic aldehydes afforded either the triazole derivatives 10a–d or Schiff base 11. In
addition, the behaviour of compound 1 towards activated unsaturated compounds namely
dimethyl acetylen
您可能关注的文档
- an unbiased scientific record should be everyone's agenda一个公正的科学记录应每个人的议程.pdf
- [5-(1,3-diphenyl-1h-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol-1-yl](pyridin-4-yl)methanone英文论文.pdf
- a standard addition method to assay the concentration of biologically interesting polyphenols in grape berries by reversed-phase hplc一个标准添加法测定的浓度生物有趣的多酚类物质在葡萄浆果反相高效液相色谱法.pdf
- antioxidant, total phenolic content and cytotoxicity evaluation of selected malaysian plants抗氧化剂,总酚含量和细胞毒性的评价选择马来西亚植物.pdf
- amélioration de la productivité des brebis berrichonnes du cher par croisement. iii. – performances de reproduction des trois premières genérations de brebis croisées entre les races berrichonne du cher et romanov英文论文.pdf
- carnivory in the teasel dipsacus fullonum — the effect of experimental feeding on growth and seed set在川续断carnivory dipsacus fullonumu2014u2014实验喂养对增长的影响和种子.pdf
- common variants in crp and lepr influence high sensitivity c-reactive protein levels in north indians常见的变体c反应蛋白和lepr影响灵敏度高c反应蛋白水平在北印度人.pdf
- arntl (bmal1) and npas2 gene variants contribute to fertility and seasonalityarntl(bmal1)和npas2基因变异导致生育和季节性.pdf
- cost-effectiveness of blood agar for isolation of mycobacteria成本效益的血琼脂分枝杆菌的隔离.pdf
- depression, anxiety and glucose metabolism in the general dutch population the new hoorn study抑郁、焦虑和葡萄糖代谢一般荷兰人口新hoorn研究.pdf
- 一级建造师之一建市政公用工程实务综合提升练习试题包含答案.docx
- 一级建造师之一建市政公用工程实务通关模拟题库包括详细解答.docx
- 如何培养孩子的自理能力课件.ppt
- 2022-2023年社会工作者之中级社会综合能力综合提升练习题库提供答案解析.docx
- 如何培养孩子良好的生活行为习惯.ppt
- 一级建造师之一建市政公用工程实务综合提升模拟卷和答案.docx
- 一级建造师之一建市政公用工程实务考前冲刺练习题库包括详细解答.docx
- 2023年一级建造师之一建市政公用工程实务模拟卷包含答案.docx
- 护理查房ppt sbar模式.pptx
- 2022-2023年中级银行从业资格之中级风险管理考前冲刺训练试卷包括详细解答.docx
最近下载
- 在线考试系统流程图参照.pdf VIP
- 2023年中小学教师高级职称专业水平能力试题库及答案(通用版).pdf
- NB∕T 10618-2021 在役乙烯裂解炉辐射段炉管检验、评估与维护导则.pdf
- 第三单元商业贸易与日常生活综合复习训练 高二上学期历史统编版(2019)选择性必修二.docx VIP
- 小区物业服务投标方案.docx
- 为中华之崛起而读书(完整版)(完美版).pptx
- 幼儿园小班美术《甜甜的西瓜》 课件.pptx
- 2023年护理考试-护理学(副高)考试历年真题荟萃带答案.docx
- 2024云南新华书店集团限公司公开招聘34人公开引进高层次人才和急需紧缺人才笔试参考题库(共500题)答案详解版.docx
- 【美术课件】过山车.pptx
文档评论(0)