原创力文档the origin and evolutionary history of hiv-1 subtype c in senegalhiv - 1亚型的起源和进化历史c在塞内加尔.pdfVIP
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the origin and evolutionary history of hiv-1 subtype c in senegalhiv - 1亚型的起源和进化历史c在塞内加尔
The Origin and Evolutionary History of HIV-1 Subtype C
in Senegal
1,2 1,3 1 4 3
Matthieu Jung , Nafissatou Leye , Nicole Vidal , Denis Fargette , Halimatou Diop , Coumba Toure
3 2 1
Kane , Olivier Gascuel *, Martine Peeters *
´ ´
1 UMI233, TransVIHMI, IRD (Institut de Recherche pour le Developpement) and University of Montpellier 1, Montpellier, France, 2 UMR 5506, Methodes et Algorithmes
´
pour la Bioinformatique, Laboratoire d’Informatique, de Robotique et de Microelectronique de Montpellier, CNRS and University of Montpellier 2, Montpellier, France,
´
3 Laboratory of Bacteriology and Virology, Le Dantec University Teaching Hospital, Dakar, Senegal, 4 UMR RPB, Institut de Recherche pour le Developpement, La
´
Recherche Agronomique pour le Developpement and University of Montpellier 2, Montpellier, France
Abstract
Background: The classification of HIV-1 strains in subtypes and Circulating Recombinant Forms (CRFs) has helped in
tracking the course of the HIV pandemic. In Senegal, which is located at the tip of West Africa, CRF02_AG predominates in
the general population and Female Sex Workers (FSWs). In contrast, 40% of Men having Sex with Men (MSM) in Senegal are
infected with subtype C. In this study we analyzed the geographical origins an
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