the role of molecular pathology in the diagnosis of cutaneous lymphomas分子病理学的作用在皮肤淋巴瘤的诊断.pdfVIP

Hindawi Publishing Corporation Pathology Research International Volume 2012, Article ID 913523, 10 pages doi:10.1155/2012/913523 Review Article The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas Philipp W. Raess and Adam Bagg Department of Pathology and Laboratory Medicine, University of Pennsylvania, 7.103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA Correspondence should be addressed to Adam Bagg, adambagg@ Received 1 August 2012; Accepted 18 October 2012 Academic Editor: Gary Tse Copyright © 2012 P. W. Raess and A. Bagg. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted. Recent advances in the understanding of the molecular pathogenesis of various cutaneous lymphomas are discussed. Some of these nascent discoveries may lead to the development of diagnostically useful molecular assays. 1. Introduction 2. Antigen Receptor Gene Rearrangements Cutaneous lymphoproliferations remain a challenging area 2.1. Generation of Immunological Diversity. An understand- to both