原创力文档the role of mir-103 and mir-107 in regulation of cdk5r1 expression and in cellular migrationmir - 103的作用,mir - 107 cdk5r1表达的调控和细胞迁移.pdfVIP
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The Role of miR-103 and miR-107 in Regulation of
CDK5R1 Expression and in Cellular Migration
1 2 1 3,4 3
Silvia Moncini , Alessandro Salvi , Paola Zuccotti , Gabriella Viero , Alessandro Quattrone , Sergio
2 2 1 1
Barlati , Giuseppina De Petro , Marco Venturin , Paola Riva *
1 Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy, 2 Division of Biology and Genetics, Department of Biomedical Sciences and
Biotechnology, University of Brescia, Brescia, Italy, 3 Centre for Integrative Biology (CIBIO), University of Trento, Trento, Italy, 4 Institute of Biophysics, National Research
Council, Trento, Italy
Abstract
CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development
and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS
function, suggesting that a tightly controlled regulation of CDK5R1 expression is needed for proper CDK5 activity.
Accordingly, CDK5R1 expression was demonstrated to be controlled at both transcriptional and post-transcriptional levels,
but a possible regulation through microRNAs (miRNAs) has never been investigated. We predicted, within the large CDK5R1
39UTR several miRNA target sites. Among them, we selected for functional studies miR-103 and miR-107, whose expression
has shown a strong inverse correlation with p35 levels in different cell lines. A significant reduction of CDK5R1 mRNA and
p35 levels was observed after transfection of SK-N-BE neuroblastoma cells with the miR-103 or miR-107 precursor (pre-miR-
1
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