原创力文档the role of regulatory t cells in antigen-induced arthritis aggravation of arthritis after depletion and amelioration after transfer of cd4+cd25+ t cells调节性t细胞的作用antigen-induced关节炎加重关节炎的枯竭和改良后的转移cd4 + cd25 + t细胞.pdfVIP
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theroleofregulatorytcellsinantigen-inducedarthritisaggravationofarthritisafterdepletionandameliorationaftertransferofcd4cd25tcells调节性t细胞的作用antigen-induced关节炎加重关节炎的枯竭和改良后的转移cd4cd25t细胞
Available online /content/7/2/R291
Vol 7 No 2 Open Access
Research article
The role of regulatory T cells in antigen-induced arthritis:
aggravation of arthritis after depletion and amelioration after
transfer of CD4+CD25+ T cells
1 1 1 2 2
Oliver Frey , Peter K Petrow , Mieczyslaw Gajda , Kerstin Siegmund , Jochen Huehn ,
3 2 3 1
Alexander Scheffold , Alf Hamann , Andreas Radbruch and Rolf Bräuer
1Institut fur Pathologie, Friedrich-Schiller-Universität, Jena, Germany
2Experimentelle Rheumatologie, Medizinische Klinik, Charité, Humboldt-Universität, c/o Deutsches Rheuma-Forschungszentrum, Berlin, Germany
3Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Corresponding author: Rolf Bräuer, rolf.braeuer@med.uni-jena.de
Received: 1 Nov 2004 Revisions requested: 17 Nov 2004 Revisions received: 18 Nov 2004 Accepted: 24 Nov 2004 Published: 11 Jan 2005
Arthritis Res Ther 2005, 7:R291-R301 (DOI 10.1186/ar1484)
/content/7/2/R291
© 2005 Frey et al., licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited.
Abstract
+ + into immunized mice at the time of induction of antigen-induced
It is now generally accepted that CD4
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