the role of receptor for advanced glycation endproducts (rage) in infection受体对高级糖基化终末产物的作用(愤怒)感染.pdfVIP

van Zoelen et al. Critical Care 2011, 15:208 /content/15/2/208 R E V I E W The role of receptor for advanced glycation endproducts (RAGE) in infection Marieke AD van Zoelen*, Ahmed Achouiti, Tom van der Poll This article is one of eleven reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2011 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be found online at /series/annual. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from /series/8901 Introduction apoptotic cells [4] and have activating eff ects on receptor- During evolution, multicellular organisms have devel oped expressing cells engaged in host defense. DAMPs can also an impressive arsenal of defense and repair mechanisms to be detected by TLRs and NLRs and their engagement counteract threats such as infection and trauma. Such an induces NF-κB activation as well, suggesting that DAMPs infl ammatory response begins with the detection of the and PAMPs use, at least partially, the same receptors and potential life-threatening event by recognizing so-called signaling pathways. Liu et al. [5] however, propose that the danger signals. h ese signal molecules have been classi- immune system treats DAMPs and PAMPs diff erently; cally divided into: i) Exogenous, pathogen-associated they suggest that DAMPs – but not PAMPs – bring CD24- molecular patterns (PAMPs) [1], which are con served Siglec G/10 into the proximity of TLRs/NLRs, resulting in motifs on pathogens that are not found in higher eukaryo- repressed DAMP-induced TLR/NLR signaling. cytes; a