原创力文档the role of structural genes in the pathogenesis of osteoarthritic disorders结构基因的作用在骨关节炎的疾病的发病机制.pdfVIP
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the role of structural genes in the pathogenesis of osteoarthritic disorders结构基因的作用在骨关节炎的疾病的发病机制
Available online /content/4/6/337
Review
The role of structural genes in the pathogenesis of osteoarthritic
disorders
Anthony M Reginato1,2 and Bjorn R Olsen1
1Department of Cell Biology, Harvard Medical School, Boston, MA, USA
2Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA USA
Corresponding author: Bjorn R Olsen (e-mail: bjorn_olsen@)
Received: 22 May 2002 Revisions received: 22 July 2002 Accepted: 26 July 2002 Published: 30 August 2002
Arthritis Res 2002, 4:337-345 (DOI 10.1186/ar595)
© 2002 BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)
Abstract
Osteoarthritis (OA), one of the most common age-related chronic disorders of articular cartilage, joints,
and bone tissue, represents a major public health problem. Genetic studies have identified multiple
gene variations associated with an increased risk of OA. These findings suggest that there is a large
genetic component to OA and that the disorder belongs in the multigenetic, multifactorial class of
genetic diseases. Studies of chondrodysplasias and associated hereditary OA have provided a better
understanding of the role of structural genes in the maintenance and repair of articular cartilage, in the
regulation of chondrocyte proliferation and gene expression, and in the pathogenesis of OA.
Keywords: cartilage, chromosomes, genetics, linkage, osteoarthritis
Introduction Articular cartilage is composed of an extracellular matrix
Osteoarthritis (OA), the most common form of arthritis, is designed to resist tensile and compressive forces an
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