原创力文档the rhoptry proteins rop18 and rop5 mediate toxoplasma gondii evasion of the murine, but not the human, interferon-gamma responserhoptry蛋白质rop18和rop5调解刚地弓形虫鼠的逃避,但不是人类,移行细胞反应.pdfVIP
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the rhoptry proteins rop18 and rop5 mediate toxoplasma gondii evasion of the murine, but not the human, interferon-gamma responserhoptry蛋白质rop18和rop5调解刚地弓形虫鼠的逃避,但不是人类,移行细胞反应
The Rhoptry Proteins ROP18 and ROP5 Mediate
Toxoplasma gondii Evasion of the Murine, But Not the
Human, Interferon-Gamma Response
1 1 1 1,2 1,3
Wendy Niedelman , Daniel A. Gold , Emily E. Rosowski , Joris K. Sprokholt , Daniel Lim , Ailan Farid
4 1 5 1,3 1
Arenas , Mariane B. Melo , Eric Spooner , Michael B. Yaffe , Jeroen P. J. Saeij *
1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 2 Department of Cell Biology and Immunology,
Wageningen University and Research Centre, Wageningen, The Netherlands, 3 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology,
Cambridge, Massachusetts, United States of America, 4 Group of Molecular Parasitology, Universidad del Quindio, Quindio, Colombia, 5 Whitehead Institute for
Biomedical Research, Cambridge, Massachusetts, United States of America
Abstract
The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the
immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are
prevalent in North America and Europe, have identified several secreted effectors that determine strain differences in mouse
virulence. The polymorphic rhoptry protein kinase ROP18 was recently shown to determine the difference in virulence
between type I and III strains by phosphorylating and inactivating the interferon-c (IFNc)-induced immunity-related GTPases
(IRGs) t
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