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the rip140 gene is a transcriptional target of e2f1rip140基因转录e2f1的目标
The RIP140 Gene Is a Transcriptional Target of E2F1
´ 1,2,3 1,2,3 1,2,3 1,2,3¤a
Aurelie Docquier , Patrick Augereau , Marion Lapierre , Pierre-Olivier Harmand ,
1,2,3¤b ´ 1,2,3¤c 1,2,3¤c ` 1,2,3
Eric Badia , Jean-Sebastien Annicotte , Lluis Fajas , Vincent Cavailles *
´ ´
1 IRCM, Institut de Recherche en Cancerologie de Montpellier, and INSERM, U896, Montpellier, France, 2 Universite Montpellier1, Montpellier, France, 3 CRLC Centre
´
Regional de Lutte contre le Cancer Val d’Aurelle Paul Lamarque, Montpellier, France
Abstract
RIP140 is a transcriptional coregulator involved in energy homeostasis and ovulation which is controlled at the
transcriptional level by several nuclear receptors. We demonstrate here that RIP140 is a novel target gene of the E2F1
transcription factor. Bioinformatics analysis, gel shift assay, and chromatin immunoprecipitation demonstrate that the
RIP140 promoter contains bona fide E2F response elements. In transiently transfected MCF-7 breast cancer cells, the RIP140
promoter is transactivated by overexpression of E2F1/DP1. Interestingly, RIP140 mRNA is finely regulated during cell cycle
progression (5-fold increase at the G1/S and G2/M transitions). The positive regulation by E2F1 requires sequences located
in the proximal region of the promoter (2
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