the risk of obesity by assessing infant growth against the uk-who charts compared to the uk90 reference findings from the born in bradford birth cohort study肥胖的风险评估婴儿对英国增长图表相比uk90参考发现出生在布拉德福德出生队列研究.pdfVIP
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the risk of obesity by assessing infant growth against the uk-who charts compared to the uk90 reference findings from the born in bradford birth cohort study肥胖的风险评估婴儿对英国增长图表相比uk90参考发现出生在布拉德福德出生队列研究
Johnson et al. BMC Pediatrics 2012, 12:104
/1471-2431/12/104
RESEARCH ARTICLE Open Access
The risk of obesity by assessing infant growth
against the UK-WHO charts compared to the
UK90 reference: findings from the Born in
Bradford birth cohort study
William Johnson1*, John Wright2 and Noël Cameron3
Abstract
Background: The new growth charts in the UK, the UK-WHO charts, comprise prescriptive data from the WHO
standard between two weeks and four years of age. Little is known about the development of obesity risk in
normal UK infants, who are necessarily not fed according to the WHO recommendations and do not live in
constraint-free environments (the selection criteria of the WHO standard source sample), using the new charts.
Here, we investigated infant growth trajectories and traits indicative of childhood obesity using the UK-WHO charts,
with the aim to clearly document the implications of adopting the new charts on UK growth monitoring practice.
Methods: Mixed effects models were applied to serial weight and length data from 2181 infants (1187 White; 994
Pakistani) in the Born in Bradford birth cohort study to produce curves from 10 days to 15 months of age.
Individual monthly estimates were converted to Z-scores and were plotted by sex and ethnic group. The relative
risks (RR) of traits indicative of childhood obesity, including high BMI and rapid weight gain, using the UK-WHO
charts compared to the previously used UK90 reference were calculated for all infants together and for White and
Pakistani infants separately.
Results: Both ethnic groups demonstrated patterns of growth similar to the UK-WHO charts in length but not in
weight. The resulting pattern for BMI was remarkable, with an average gain of 1.0 Z-score between two and
12 months of age. The UK-WHO charts were significantly (p 0.05) more likely t
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