原创力文档the risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents上消化道并发症的风险与非甾体类抗炎药、糖皮质激素,对乙酰氨基酚,这些代理的组合.pdfVIP
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the risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents上消化道并发症的风险与非甾体类抗炎药、糖皮质激素,对乙酰氨基酚,这些代理的组合
Available online /content/3/2/098
Review
The risk of upper gastrointestinal complications associated with
nonsteroidal anti-inflammatory drugs, glucocorticoids,
acetaminophen, and combinations of these agents
Luis Alberto García Rodríguez* and Sonia Hernández-Díaz†
*Spanish Center for Pharmacoepidemiological Research (CEIFE), Madrid, Spain
†Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Correspondence: Dr Luis Alberto García Rodríguez, Spanish Center for Pharmacoepidemiological Research (CEIFE), Almirante 28-2, 28004 Madrid,
Spain. Tel: +34 91 531 3404; fax: +34 91 531 2871; e-mail: lagarcia@ceife.es
Received: 30 October 2000 Arthritis Res 2001, 3:98–101
Revisions requested: 13 November 2000 This article may contain supplementary data which can only be found
Revisions received: 14 November 2000 online at /content/3/2/098
Accepted: 22 November 2000 © 2001 BioMed Central Ltd
Published: 15 December 2000 (Print ISSN 1465-9905; Online ISSN 1465-9913)
Abstract
Most anti-inflammatory drugs have been associated with an increased risk of serious upper
gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for
specific anti-inflammatory drugs. The risk of upper gastrointestinal tract bleeding or perforation
increases around twofold with use of oral steroids or low dose aspirin, and increases around fourfold
with use of nonaspirin nonsteroidal anti-inflammatory drugs. Acetaminophen at daily doses of 2000mg
and higher has also been associated with an increased risk. Overall, the risk is dose d
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