the proinflammatory cytokines il-2, il-15 and il-21 modulate the repertoire of mature human natural killer cell receptors促炎细胞因子- 2,il-15 il-21调节人类自然杀伤细胞受体的成熟.pdfVIP

Available online /content/9/6/R125 Vol 9 No 6 Open Access Research article The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors 1 1 1 1 2 Casimir de Rham , Sylvie Ferrari-Lacraz , Sabrina Jendly , Gregory Schneiter , Jean-Michel Dayer and Jean Villard1 1Transplantation Immunology Unit, Department of Internal Medicine, University Hospital, rue Micheli-du-Crest, Geneva 14, 1211, Switzerland 2Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, rue Micheli-du-Crest, Geneva 14, 1211, Switzerland Corresponding author: Jean Villard, jean.villard@hcuge.ch Received: 20 Jul 2007 Revisions requested: 27 Sep 2007 Revisions received: 23 Oct 2007 Accepted: 3 Dec 2007 Published: 3 Dec 2007 Arthritis Research Therapy 2007, 9:R125 (doi:10.1186/ar2336) This article is online at: /content/9/6/R125 © 2007 de Rham et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Natural killer (NK) cells play a crucial role in the immune cells on a large scale. IL-2 and IL-15 may induce the expression response to micro-organisms and tumours. Recent evidence of killer cell immunoglobulin-like receptors (KIRs) in KIR- suggests that NK cells also regulate the adaptive T-cell negat