the role of the complement and the fcγr system in the pathogenesis of arthritis补充的角色和fcγr系统在关节炎的发病机制.pdfVIP

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the role of the complement and the fcγr system in the pathogenesis of arthritis补充的角色和fcγr系统在关节炎的发病机制.pdf

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the role of the complement and the fcγr system in the pathogenesis of arthritis补充的角色和fcγr系统在关节炎的发病机制

Available online /contents/7/4/129 Review γγ The role of the complement and the Fc R system in the pathogenesis of arthritis 1 1 1,2,3 Samuel Solomon , Daniela Kassahn and Harald Illges 1Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany 2Biotechnology Institute Thurgau, Tägerwilen, Switzerland 3University of Applied Sciences, Department of Natural Sciences, Immunology and Cell Biology, Rheinbach, Germany Corresponding author: Harald Illges, harald.illges@fh-brs.de Published: 16 May 2005 Arthritis Research Therapy 2005, 7:129-135 (DOI 10.1186/ar1761) This article is online at /content/7/4/129 © 2005 BioMed Central Ltd Abstract More recently, autoantibodies against citrullinated proteins Autoantibodies in sera from patients with autoimmune diseases have been shown to be specifically present in patients with have long been known and have become diagnostic tools. Analysis RA [4]. Studies involving animal models have shed more light of their functional role again became popular with the availability of on the role of autoantibodies in the pathogenesis of the mice mutant for several genes of the complement and Fcγ receptor disease [5,6]. There has been increasing evidence of the (FcγR) systems. Evidence from different inflammatory models importance of autoantibodies and innate immunity cellular suggests that both systems are interconnected in a hierarc