the role of the notch pathway in healthy and osteoarthritic articular cartilage from experimental models to ex vivo studiesnotch通路的作用在健康和骨关节炎的关节软骨体外研究从实验模型.pdfVIP

Sassi et al. Arthritis Research Therapy 2011, 13:208 /content/13/2/208 R E V I E W The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies 1,2 2 3 2 1 2 Nadia Sassi* , Lilia Laadhar , Maha Driss , Meriam Kallel-Sellami , Slaheddine Sellami and Sondes Makni muta genesis and misexpression of Notch and its ligands Abstract have highlighted numerous roles of this pathway during Osteoarthritis is the most prevalent form of arthritis embryogenesis and the early stages of development [3-5]. in the world. With the progressive ageing of the Notch signaling has been identifi ed in diff erent develop- population, it is becoming a major public health mental systems, especially neurogenesis [3,4] and hemato- problem. The involvement of certain signaling poeisis [5]. h ese studies show that Notch signaling, in pathways, such as the Notch pathway, during cartilage combination with other cellular factors, infl uences pathology has been reported. In this review, we report diff erentiation, proliferation and apoptosis. on studies that investigated the expression pattern h e Notch signaling pathway is highly conserved, from of the Notch family members in articular cartilage worms to humans. It is considered an important pathway and the eventual involvement of this pathway in in the development and assignment of cell fates during the modulation of the physiology and pathology o