the role of the p2x7 receptor in infectious diseasesp2x7受体在传染病的作用.pdfVIP

Review The Role of the P2X7 Receptor in Infectious Diseases 1 1 2 1 1 Catherine M. Miller , Nicola R. Boulter , Stephen J. Fuller , Alana M. Zakrzewski , Michael P. Lees , 3 4 5 Bernadette M. Saunders , James S. Wiley , Nicholas C. Smith * 1 Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Broadway, New South Wales, Australia, 2 Nepean Clinical School, Nepean Hospital, The University of Sydney, Penrith, New South Wales, Australia, 3 Centenary Institute of Cancer Medicine Cell Biology, The University of Sydney, Camperdown, New South Wales, Australia, 4 Florey Neuroscience Institute, The University of Melbourne, Parkville, Victoria, Australia, 5 Queensland Tropical Health Alliance, Faculty of Medicine, Health and Molecular Sciences, James Cook University, Smithfield, Cairns, Queensland, Australia membrane-spanning segments, separated by an extracellular loop Abstract: ATP is an extracellular signal for the immune containing ten conserved cysteine residues, thought to form system, particularly during an inflammatory response. It is disulfide bonds, and lysine and phenylalanine residues involved sensed by the P2X7 receptor, the expression of which is in activation by ATP [7]. The C termini of the various P2X upregulated by pro-inflammatory cytokines. Activation of subunits vary in length from 25 amino acids in the P2X6 receptor the P2X7 receptor opens a cation-specific channel that