原创力文档the role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance传输机制的作用在结核分枝杆菌耐药性和宽容.pdfVIP
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the role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance传输机制的作用在结核分枝杆菌耐药性和宽容
Pharmaceuticals 2012, 5, 1210-1235; doi:10.3390/ph5111210
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Role of Transport Mechanisms in Mycobacterium
Tuberculosis Drug Resistance and Tolerance
Jansy Passiflora Sarathy 1, Véronique Dartois 1,2,†,* and Edmund Jon Deoon Lee 3
1 Novartis Institute for Tropical Diseases Pte Ltd, 10 Biopolis Road #05-01, Chromos, 138670,
Singapore
2 Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543,
Singapore
3 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of
Singapore, Clinical Research Centre, 10 Medical Drive, 117597, Singapore
† Current address: Public Health Research Institute, 225 Warren St, Newark, NJ 07103, USA.
* Author to whom correspondence should be addressed; E-Mail: dartoiva@;
Tel.: +1-973-854-3160.
Received: 27 August 2012; in revised form: 25 October 2012 / Accepted: 2 November 2012 /
Published: 9 November 2012
Abstract: In the fight against tuberculosis, cell wall permeation of chemotherapeutic
agents remains a critical but largely unsolved question. Here we review the major
mechanisms of small molecule penetration into and efflux from Mycobacterium
tuberculosis and other mycobacteria, and outline how these mechanisms may contribute to
the development of phenotypic drug tolerance and induction of drug resistance.
M. tuberculosis is intrinsically recalcitrant to small molecule permeation thanks to its thick
lipid
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