the ring between ring fingers (rbr) protein family戒指在无名指(rbr)蛋白家族.pdfVIP

Protein family review The ring between ring fingers (RBR) protein family † Birgit Eisenhaber*, Nina Chumak , Frank Eisenhaber* and Marie-Theres Hauser† Addresses: *Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse, A-1030 Vienna, Austria. †Institute of Applied Genetics and Cell Biology, Department of Plant Science and Plant Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse, A-1190 Vienna, Austria. Correspondence: Birgit Eisenhaber. Email: Birgit.Eisenhaber@imp.univie.ac.at. Marie-Theres Hauser. Email: Marie-Theres.Hauser@boku.ac.at Published: 15 March 2007 Genome Biology 2007, 8:209 (doi:10.1186/gb-2007-8-3-209) The electronic version of this article is the complete one and can be found online at /2007/8/3/209 © 2007 BioMed Central Ltd Summary Proteins of the ring between ring fingers (RBR)-domain family are characterized by three groups of specifically clustered (typically eight) cysteine and histidine residues. Whereas the amino- terminal ring domain (N-RING) binds two zinc ions and folds into a classical cross-brace ring finger, the carboxy-terminal ring domain (C-RING) involves only one zinc ion. The three- dimensional structure of the central ring domain, the IBR domain, is still unsolved. About 400 genes coding for RBR proteins have been identified in the genomes of uni- and multicellular eukaryotes and some of their viruses, but the family has not been found in archaea or bacteria. The RBR proteins are classified into 15 major subfamilies (besides some orphan cases) by the phylogenetic relationships of the RBR segments and the conservation of their se