the role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia中枢神经系统的作用在慢性疼痛的生成和维护类风湿性关节炎、骨关节炎和纤维肌痛.pdfVIP

Lee et al. Arthritis Research Therapy 2011, 13:211 /content/13/2/211 R E V I E W The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and i bromyalgia 1 1 2 Yvonne C Lee *, Nicholas J Nassikas and Daniel J Clauw initia tive to increase awareness and call for organized Abstract research and education [1]. h is initiative emphasizes the Pain is a key component of most rheumatologic need for high-quality, quantitative research to understand diseases. In i bromyalgia, the importance of central the mechanisms underlying individual diff erences in pain nervous system pain mechanisms (for example, loss of among patients with rheumatic disease. Currently, most descending analgesic activity and central sensitization) advances in the study of pain mechanisms have been in is well documented. A few studies have also noted non-infl ammatory diseases, such as fi bromyalgia [2]. alterations in central pain processing in osteoarthritis, h ese studies have highlighted the role of central pain- and some data, including the observation of processing mechanisms, such as loss of descending widespread pain sensitivity, suggest that central analgesic activity and central pain augmentation or sensi- pain-processing defects may alter the pain response tization. Some pain researchers also believe that these in rheumatoid arthritis patients. When central pain is mechanism