the retinoic acid binding protein crabp2 is increased in murine models of degenerative joint disease视黄酸结合蛋白crabp2增加退化性关节疾病的小鼠模型.pdfVIP

Available online /content/11/1/R14 Vol 11 No 1 Open Access Research article The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease 1 2 3 2 Ian D Welch , Matthew F Cowan , Frank Beier and Tully M Underhill 1Department of Animal Care and Veterinary Services, University of Western Ontario, London, Ontario, N6A 5C1, Canada 2Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada 3Department of Physiology and Pharmacology, CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, N6A 5C1, Canada Corresponding author: Tully M Underhill, tunderhi@brc.ubc.ca Received: 12 Sep 2008 Revisions requested: 12 Nov 2008 Revisions received: 4 Dec 2008 Accepted: 28 Jan 2009 Published: 28 Jan 2009 Arthritis Research Therapy 2009, 11:R14 (doi:10.1186/ar2604) This article is online at: /content/11/1/R14 © 2009 Welch et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Osteoarthritis (OA) is a debilitating disease with surgeries. PMX surgery was slightly more severe and produced poorly defined aetiology. Multiple signals are involved in significant changes in joint score at six (n = 4, p 0.01), eight directing the formation of cartilage during development and the (n =