the reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle基因网络的反向胆固醇运输途径提高理解牛肉脂肪沉积和肌肉生长.pdfVIP

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the reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle基因网络的反向胆固醇运输途径提高理解牛肉脂肪沉积和肌肉生长.pdf

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the reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle基因网络的反向胆固醇运输途径提高理解牛肉脂肪沉积和肌肉生长

The Reverse Cholesterol Transport Pathway Improves Understanding of Genetic Networks for Fat Deposition and Muscle Growth in Beef Cattle 1 2 1 1 1 Tyler F. Daniels , Xiao-Lin Wu , Zengxiang Pan , Jennifer J. Michal , Raymond W. Wright Jr. , Karen M. 3 4 1 Killinger , Michael D. MacNeil , Zhihua Jiang * 1 Department of Animal Sciences, Washington State University, Pullman, Washington, United States of America, 2 Department of Dairy Science, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, 3 School of Food Science, Washington State University, Pullman, Washington, United States of America, 4 USDA- ARS, Fort Keogh Livestock and Range Research Laboratory, Miles City, Montana, United States of America Abstract In the present study, thirteen genes involved in the reverse cholesterol transport (RCT) pathway were investigated for their associations with three fat depositions, eight fatty acid compositions and two growth-related phenotypes in a Wagyu x Limousin reference population, including 6 F1 bulls, 113 F1 dams, and 246 F2 progeny. A total of 37 amplicons were used to screen single nucleotide polymorphisms (SNPs) on 6 F1 bulls. Among 36 SNPs detected in 11 of these 13 genes, 19 were selected for genotyping by the Sequenom assay design on all F2 progeny. Single-marker analysis revealed seven SNPs in ATP binding cassette A1, apolipoproteins A1, B and E, phospholipid transfer protein and paraoxinase 1 genes significantly associated with nine phenotypes (P,0.05). Previously, we reported genetic networks associated with 19 complex phenotypes based on a total of 138 genetic polymorphisms derive