the reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines反转录抑制剂abacavir显示前列腺癌抗癌活动细胞系.pdfVIP
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the reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines反转录抑制剂abacavir显示前列腺癌抗癌活动细胞系
The Reverse Transcription Inhibitor Abacavir Shows
Anticancer Activity in Prostate Cancer Cell Lines
1. 1. 2 1 2
Francesca Carlini , Barbara Ridolfi , Agnese Molinari , Chiara Parisi , Giuseppina Bozzuto , Laura
2 2 1 3 ` 4
Toccacieli , Giuseppe Formisano , Daniela De Orsi , Silvia Paradisi , OlI Maria Victoria Grober , Maria
4 4,5 1 1 1
Ravo , Alessandro Weisz , Romano Arcieri , Stefano Vella , Simona Gaudi *
` `
1 Department of Therapeutic Research and Drug Evaluation, Istituto Superiore di Sanita, Rome, Italy, 2 Department of Technology and Health, Istituto Superiore di Sanita,
`
Rome, Italy, 3 Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy, 4 Department of General Pathology, Second University of Naples,
Naples, Italy, 5 Laboratory of Molecular Medicine, Faculty of Medicine, University of Salerno, Salerno, Italy
Abstract
Background: Transposable Elements (TEs) comprise nearly 45% of the entire genome and are part of sophisticated
regulatory network systems that control developmental processes in normal and pathological conditions. The retroviral/
retrotransposon gene machinery consists mainly of Long Interspersed Nuclear Elements (LINEs-1) and Human En
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