the stimulation of igf-1r expression by lewis(y) antigen provides a powerful development mechanism of epithelial ovarian carcinoma刘易斯igf-1r表达式的刺激(y)抗原提供了一个强大的卵巢上皮癌的发展机制.pdfVIP
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the stimulation of igf-1r expression by lewis(y) antigen provides a powerful development mechanism of epithelial ovarian carcinoma刘易斯igf-1r表达式的刺激(y)抗原提供了一个强大的卵巢上皮癌的发展机制
Int. J. Mol. Sci. 2011, 12, 6781-6795; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
The Stimulation of IGF-1R Expression by Lewis(y) Antigen
Provides a Powerful Development Mechanism of Epithelial
Ovarian Carcinoma
Dawo Liu 1, Juanjuan Liu 1, Changzhi Wang 2, Bei Lin 1,*, Qing Liu 1, Yingying Hao 1,
Shulan Zhang 1 and Masao Iwamori 3
1
Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical
University, Shenyang 110004, China; E-Mails: cyldw2007@163.com (D.L.);
juanjuanliu_lg@ (J.L.); qingLiu@126.com (Q.L.); liushuicc@ (Y.H.);
zhangshl99@126.com (S.Z.)
2
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Dalian Medical University,
Dalian 116027, China; E-Mail: changzhix_wang@
3 Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3-4-1 Kowakae,
Higashiosaka, Osaka 577-8502, Japan; E-Mail: iwamori@163.com
* Author to whom correspondence should be addressed; E-Mail: linbei88@;
Tel.: +86-24-96615-1-41511.
Received: 9 August 2011; in revised form: 26 September 2011 / Accepted: 30 September 2011 /
Published: 14 October 2011
Abstract: Objective: This study aimed to measure and correlate the expression of
insulin-like growth factor receptor-1 (IGF-1R) and the Lewis(y) antigen in ovarian cancer
cell lines and tissue samples. Methods: Reverse transcriptase PCR (RT-PC
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