the subcommissural organ of the rat secretes reissners fiber glycoproteins and csf-soluble proteins reaching the internal and external csf compartments老鼠的联合下器官分泌赖斯纳氏纤维糖蛋白和csf-soluble蛋白质达到内部和外部的csf隔间.pdfVIP

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the subcommissural organ of the rat secretes reissners fiber glycoproteins and csf-soluble proteins reaching the internal and external csf compartments老鼠的联合下器官分泌赖斯纳氏纤维糖蛋白和csf-soluble蛋白质达到内部和外部的csf隔间.pdf

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the subcommissural organ of the rat secretes reissners fiber glycoproteins and csf-soluble proteins reaching the internal and external csf compartments老鼠的联合下器官分泌赖斯纳氏纤维糖蛋白和csf-soluble蛋白质达到内部和外部的csf隔间

Cerebrospinal Fluid Research BioMed Central Research Open Access The subcommissural organ of the rat secretes Reissners fiber glycoproteins and CSF-soluble proteins reaching the internal and external CSF compartments Karin Vio, Sara Rodríguez, Carlos R Yulis, Cristian Oliver and Esteban M Rodríguez* Address: Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile Email: Karin Vio - karinvio@uach.cl; Sara Rodríguez - srodrig2@uach.cl; Carlos R Yulis - cyulis@uach.cl; Cristian Oliver - coliver@uach.cl; Esteban M Rodríguez* - erodrigu@uach.cl * Corresponding author Published: 24 January 2008 Received: 3 October 2007 Accepted: 24 January 2008 Cerebrospinal Fluid Research 2008, 5:3 doi:10.1186/1743-8454-5-3 This article is available from: /content/5/1/3 © 2008 Vio et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The subcommissural organ (SCO) is a highly conserved brain gland present throughout the vertebrate phylum; it secretes glycoproteins into the cerebrospinal fluid (CSF), where they aggregate to form Reissners fiber (RF). SCO-spondin is the major constituent protein of RF. Evidence exists that the SCO also secretes proteins that remain soluble in the CSF. The aims of the p